Drug interactions
Nortriptyline + Ziconotide
Severity: Moderate
Nortriptyline and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide commonly causes dizziness, confusion and sedation, and nortriptyline can add to these CNS effects. Combined use may worsen impaired cognition and alertness.
What this interaction means in plain words
Nortriptyline and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Nortriptyline belongs to Central Nervous System; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant and cognitive effects.
What to do
Monitor for sedation and cognitive changes, and reduce doses of one or both agents if impairment occurs. Ziconotide labeling advises stopping or reducing the dose with significant cognitive impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Nortriptyline with Ziconotide?
MediHelp rates the interaction as moderate. Nortriptyline and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide commonly causes dizziness, confusion and sedation, and nortriptyline can add to these CNS effects. Combined use may worsen impaired cognition and alertness.
How serious is the interaction between Nortriptyline and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and cognitive changes, and reduce doses of one or both agents if impairment occurs. Ziconotide labeling advises stopping or reducing the dose with significant cognitive impairment.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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