Drug interactions
Obinutuzumab + Warfarin
Severity: Moderate
Obinutuzumab and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Obinutuzumab can cause thrombocytopenia and hemorrhagic events, so adding it to warfarin may raise bleeding risk. The effect arises from reduced platelets rather than a change in warfarin levels.
What this interaction means in plain words
Obinutuzumab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Obinutuzumab belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Additive bleeding risk from obinutuzumab-induced thrombocytopenia combined with warfarin anticoagulation.
What to do
Monitor platelet counts and INR regularly during treatment. Reduce or hold warfarin if platelets fall markedly or bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Obinutuzumab
Frequently asked questions
Can I take Obinutuzumab with Warfarin?
MediHelp rates the interaction as moderate. Obinutuzumab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Obinutuzumab can cause thrombocytopenia and hemorrhagic events, so adding it to warfarin may raise bleeding risk. The effect arises from reduced platelets rather than a change in warfarin levels.
How serious is the interaction between Obinutuzumab and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and INR regularly during treatment. Reduce or hold warfarin if platelets fall markedly or bleeding occurs.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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