Drug interactions
Ocrelizumab + Ofatumumab sc
Severity: Major
Ocrelizumab and Ofatumumab sc: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are anti-CD20 antibodies that deplete B cells, so giving them together duplicates the same effect and increases the risk of infection and hypogammaglobulinemia. Combining them is not an established strategy for multiple sclerosis.
What this interaction means in plain words
Ocrelizumab and Ofatumumab sc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate CD20-directed B-cell depletion producing additive immunosuppression.
What to do
Avoid concurrent use; when switching, account for the prolonged B-cell depletion of the earlier drug before starting the next. Monitor for infection and check immunoglobulin levels and CD19 counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Ocrelizumab with Ofatumumab sc?
MediHelp rates the interaction as major. Ocrelizumab and Ofatumumab sc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are anti-CD20 antibodies that deplete B cells, so giving them together duplicates the same effect and increases the risk of infection and hypogammaglobulinemia. Combining them is not an established strategy for multiple sclerosis.
How serious is the interaction between Ocrelizumab and Ofatumumab sc?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; when switching, account for the prolonged B-cell depletion of the earlier drug before starting the next. Monitor for infection and check immunoglobulin levels and CD19 counts.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
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