Drug interactions
Ocrelizumab + Poliovirus vaccine inactivated
Severity: Moderate
Ocrelizumab and Poliovirus vaccine inactivated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ocrelizumab depletes B cells, which can blunt antibody responses to vaccines. An inactivated poliovirus vaccine is not infectious, but the protective response may be inadequate in treated patients.
What this interaction means in plain words
Ocrelizumab and Poliovirus vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ocrelizumab-induced CD20+ B-cell depletion reduces humoral vaccine responses.
What to do
Where possible, give inactivated vaccines at least 2 weeks before starting ocrelizumab. Consider checking antibody titres afterward in patients vaccinated during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ocrelizumab and Poliovirus vaccine inactivated, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Ocrelizumab with Poliovirus vaccine inactivated?
MediHelp rates the interaction as moderate. Ocrelizumab and Poliovirus vaccine inactivated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ocrelizumab depletes B cells, which can blunt antibody responses to vaccines. An inactivated poliovirus vaccine is not infectious, but the protective response may be inadequate in treated patients.
How serious is the interaction between Ocrelizumab and Poliovirus vaccine inactivated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give inactivated vaccines at least 2 weeks before starting ocrelizumab. Consider checking antibody titres afterward in patients vaccinated during therapy.
What other medicines interact with Ocrelizumab?
MediHelp also lists interactions of Ocrelizumab with, for example, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Ocrelizumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
