Drug interactions
Octreotide + Ondansetron
Severity: Moderate
Octreotide and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and conduction abnormalities, and QT prolongation has been reported. With ondansetron, these effects may add to arrhythmic risk, especially in patients with heart disease.
What this interaction means in plain words
Octreotide and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Additive effects on cardiac conduction and repolarization, with octreotide-related bradycardia.
What to do
Obtain an ECG and monitor heart rate and electrolytes in patients with cardiac disease. Choose a different antiemetic if QTc is prolonged or bradycardia is significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Ondansetron?
MediHelp rates the interaction as moderate. Octreotide and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and conduction abnormalities, and QT prolongation has been reported. With ondansetron, these effects may add to arrhythmic risk, especially in patients with heart disease.
How serious is the interaction between Octreotide and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and monitor heart rate and electrolytes in patients with cardiac disease. Choose a different antiemetic if QTc is prolonged or bradycardia is significant.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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