Drug interactions
Octreotide + Ozanimod
Severity: Moderate
Octreotide and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and octreotide can cause bradycardia and QT prolongation. Together they may increase the risk of significant bradyarrhythmia and QT-related arrhythmias.
What this interaction means in plain words
Octreotide and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects on heart rate and cardiac repolarization.
What to do
Obtain an ECG before starting ozanimod in a patient taking octreotide and seek cardiology advice if there is a significant conduction or QT abnormality. Monitor heart rate during initiation and correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Octreotide with Ozanimod?
MediHelp rates the interaction as moderate. Octreotide and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and octreotide can cause bradycardia and QT prolongation. Together they may increase the risk of significant bradyarrhythmia and QT-related arrhythmias.
How serious is the interaction between Octreotide and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod in a patient taking octreotide and seek cardiology advice if there is a significant conduction or QT abnormality. Monitor heart rate during initiation and correct electrolyte disturbances.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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