Drug interactions
Octreotide + Telotristat etiprate
Severity: Moderate
Octreotide and Telotristat etiprate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Short-acting octreotide markedly reduces systemic exposure to telotristat and its active metabolite. This may weaken the control of carcinoid syndrome diarrhoea.
What this interaction means in plain words
Octreotide and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Telotristat etiprate belongs to Gastrointestinal Tract.
Why it happens
Octreotide's effects on gastrointestinal function reduce telotristat absorption; the exact mechanism is not fully established.
What to do
Give short-acting octreotide at least 30 minutes after telotristat. Monitor bowel movement frequency.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Octreotide and Telotristat etiprate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Telotristat etiprate
- Bupropion + Telotristat etiprate Moderate
- Capecitabine + Telotristat etiprate Moderate
- Everolimus + Telotristat etiprate Moderate
- Flutamide + Telotristat etiprate Moderate
- Irinotecan + Telotristat etiprate Moderate
- Midazolam + Telotristat etiprate Moderate
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Telotristat etiprate?
MediHelp rates the interaction as moderate. Octreotide and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Short-acting octreotide markedly reduces systemic exposure to telotristat and its active metabolite. This may weaken the control of carcinoid syndrome diarrhoea.
How serious is the interaction between Octreotide and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give short-acting octreotide at least 30 minutes after telotristat. Monitor bowel movement frequency.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Capecitabine, Everolimus. The full list is on the Telotristat etiprate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
