Drug interactions
Flutamide + Telotristat etiprate
Severity: Moderate
Flutamide and Telotristat etiprate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flutamide is a CES2 substrate and telotristat may alter carboxylesterase handling of it, so flutamide exposure could change. The clinical consequence is uncertain, but flutamide carries a risk of liver toxicity.
What this interaction means in plain words
Flutamide and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flutamide belongs to Endocrine; Telotristat etiprate belongs to Gastrointestinal Tract.
Why it happens
Possible modulation of CES2-mediated metabolism of flutamide; not well characterized clinically.
What to do
Monitor liver function tests and clinical response to flutamide when telotristat is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telotristat etiprate
- Bupropion + Telotristat etiprate Moderate
- Capecitabine + Telotristat etiprate Moderate
- Everolimus + Telotristat etiprate Moderate
- Irinotecan + Telotristat etiprate Moderate
- Midazolam + Telotristat etiprate Moderate
- Octreotide + Telotristat etiprate Moderate
Other interactions of Flutamide
Frequently asked questions
Can I take Flutamide with Telotristat etiprate?
MediHelp rates the interaction as moderate. Flutamide and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flutamide is a CES2 substrate and telotristat may alter carboxylesterase handling of it, so flutamide exposure could change. The clinical consequence is uncertain, but flutamide carries a risk of liver toxicity.
How serious is the interaction between Flutamide and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and clinical response to flutamide when telotristat is started or stopped.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Capecitabine, Everolimus. The full list is on the Telotristat etiprate page.
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