Drug interactions
Bupropion + Telotristat etiprate
Severity: Moderate
Bupropion and Telotristat etiprate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat may induce CYP2B6 and lower exposure to bupropion. This could reduce its antidepressant or smoking-cessation efficacy.
What this interaction means in plain words
Bupropion and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Telotristat etiprate belongs to Gastrointestinal Tract.
Why it happens
Possible CYP2B6 induction increasing bupropion metabolism.
What to do
Monitor clinical response to bupropion and adjust the dose if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telotristat etiprate
- Capecitabine + Telotristat etiprate Moderate
- Everolimus + Telotristat etiprate Moderate
- Flutamide + Telotristat etiprate Moderate
- Irinotecan + Telotristat etiprate Moderate
- Midazolam + Telotristat etiprate Moderate
- Octreotide + Telotristat etiprate Moderate
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Telotristat etiprate?
MediHelp rates the interaction as moderate. Bupropion and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat may induce CYP2B6 and lower exposure to bupropion. This could reduce its antidepressant or smoking-cessation efficacy.
How serious is the interaction between Bupropion and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to bupropion and adjust the dose if efficacy declines.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Capecitabine, Everolimus, Flutamide. The full list is on the Telotristat etiprate page.
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