Drug interactions
Midazolam + Telotristat etiprate
Severity: Moderate
Midazolam and Telotristat etiprate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat lowers exposure to CYP3A4 substrates such as midazolam. Sedative effect may be reduced.
What this interaction means in plain words
Midazolam and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Midazolam belongs to Central Nervous System; Telotristat etiprate belongs to Gastrointestinal Tract.
Why it happens
Induction of CYP3A4 increases midazolam metabolism.
What to do
Monitor sedation adequacy and titrate midazolam to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telotristat etiprate
- Bupropion + Telotristat etiprate Moderate
- Capecitabine + Telotristat etiprate Moderate
- Everolimus + Telotristat etiprate Moderate
- Flutamide + Telotristat etiprate Moderate
- Irinotecan + Telotristat etiprate Moderate
- Octreotide + Telotristat etiprate Moderate
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Midazolam with Telotristat etiprate?
MediHelp rates the interaction as moderate. Midazolam and Telotristat etiprate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Telotristat lowers exposure to CYP3A4 substrates such as midazolam. Sedative effect may be reduced.
How serious is the interaction between Midazolam and Telotristat etiprate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation adequacy and titrate midazolam to effect.
What other medicines interact with Telotristat etiprate?
MediHelp also lists interactions of Telotristat etiprate with, for example, Bupropion, Capecitabine, Everolimus. The full list is on the Telotristat etiprate page.
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