Drug interactions
Octreotide + Trazodone
Severity: Moderate
Octreotide and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with prolongation of the QT interval. Used together, the additive effect may raise the risk of torsades de pointes, particularly with bradycardia or electrolyte disturbances.
What this interaction means in plain words
Octreotide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Trazodone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation; octreotide effect is mainly via bradycardia and is less direct.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and heart rate, and reconsider the combination if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Octreotide and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Octreotide with Trazodone?
MediHelp rates the interaction as moderate. Octreotide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with prolongation of the QT interval. Used together, the additive effect may raise the risk of torsades de pointes, particularly with bradycardia or electrolyte disturbances.
How serious is the interaction between Octreotide and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor QTc and heart rate, and reconsider the combination if QTc becomes markedly prolonged.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
