Drug interactions
Octreotide + Valbenazine
Severity: Moderate
Octreotide and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine may prolong the QT interval at higher exposures, and octreotide can contribute QT effects and bradycardia. The combination may raise arrhythmia risk, particularly in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Octreotide and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Octreotide belongs to Endocrine; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation through pharmacodynamic effects.
What to do
Check ECG at baseline in patients with cardiac risk factors and monitor during treatment. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Octreotide with Valbenazine?
MediHelp rates the interaction as moderate. Octreotide and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine may prolong the QT interval at higher exposures, and octreotide can contribute QT effects and bradycardia. The combination may raise arrhythmia risk, particularly in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Octreotide and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline in patients with cardiac risk factors and monitor during treatment. Correct potassium and magnesium abnormalities.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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