Drug interactions
Ofatumumab sc + Vedolizumab
Severity: Moderate
Ofatumumab sc and Vedolizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and vedolizumab limits lymphocyte homing to the gut, so combining them may increase infection risk. Because vedolizumab acts mainly in the gut, the additive effect is probably modest.
What this interaction means in plain words
Ofatumumab sc and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression via B-cell depletion and alpha4beta7 integrin blockade.
What to do
Monitor for infections, especially gastrointestinal ones. When switching, allow for the prolonged immune effects of the earlier drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vedolizumab
- Natalizumab + Vedolizumab Contraindicated
- Baricitinib + Vedolizumab Major
- Certolizumab pegol + Vedolizumab Major
- Etanercept + Vedolizumab Major
- Golimumab + Vedolizumab Major
- Smallpox vaccine live + Vedolizumab Major
Frequently asked questions
Can I take Ofatumumab sc with Vedolizumab?
MediHelp rates the interaction as moderate. Ofatumumab sc and Vedolizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and vedolizumab limits lymphocyte homing to the gut, so combining them may increase infection risk. Because vedolizumab acts mainly in the gut, the additive effect is probably modest.
How serious is the interaction between Ofatumumab sc and Vedolizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infections, especially gastrointestinal ones. When switching, allow for the prolonged immune effects of the earlier drug.
What other medicines interact with Vedolizumab?
MediHelp also lists interactions of Vedolizumab with, for example, Natalizumab, Baricitinib, Certolizumab pegol. The full list is on the Vedolizumab page.
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