Drug interactions
Ofloxacin + Osilodrostat
Severity: Moderate
Ofloxacin and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Osilodrostat can also cause hypokalemia, which adds to the risk.
What this interaction means in plain words
Ofloxacin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Osilodrostat belongs to Endocrine.
Why it happens
Additive prolongation of cardiac repolarization, with osilodrostat-related hypokalemia.
What to do
Obtain an ECG at baseline and during therapy, and correct potassium and magnesium before and during use. Choose a non-QT-prolonging antibiotic when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Ofloxacin with Osilodrostat?
MediHelp rates the interaction as moderate. Ofloxacin and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Osilodrostat can also cause hypokalemia, which adds to the risk.
How serious is the interaction between Ofloxacin and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and during therapy, and correct potassium and magnesium before and during use. Choose a non-QT-prolonging antibiotic when possible.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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