Drug interactions
Ofloxacin + Osimertinib
Severity: Moderate
Ofloxacin and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so used together they may raise the risk of torsades de pointes. Patients with electrolyte abnormalities or heart disease are at greater risk.
What this interaction means in plain words
Ofloxacin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Osimertinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Perform periodic ECG and electrolyte monitoring, correcting potassium, magnesium and calcium. Use an alternative antibiotic if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Ofloxacin with Osimertinib?
MediHelp rates the interaction as moderate. Ofloxacin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so used together they may raise the risk of torsades de pointes. Patients with electrolyte abnormalities or heart disease are at greater risk.
How serious is the interaction between Ofloxacin and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECG and electrolyte monitoring, correcting potassium, magnesium and calcium. Use an alternative antibiotic if the QTc becomes markedly prolonged.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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