Drug interactions
Ofloxacin + Oxaliplatin
Severity: Major
Ofloxacin and Oxaliplatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation, and ofloxacin may add to this effect. Patients receiving chemotherapy often have electrolyte disturbances and other QT-prolonging drugs, which increases the arrhythmia risk.
What this interaction means in plain words
Ofloxacin and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ofloxacin belongs to Anti Bacterial; Oxaliplatin belongs to Oncology.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Prefer an antibiotic with less QT effect when feasible. Otherwise monitor ECG and correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Ofloxacin with Oxaliplatin?
MediHelp rates the interaction as major. Ofloxacin and Oxaliplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxaliplatin has been associated with QT prolongation, and ofloxacin may add to this effect. Patients receiving chemotherapy often have electrolyte disturbances and other QT-prolonging drugs, which increases the arrhythmia risk.
How serious is the interaction between Ofloxacin and Oxaliplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic with less QT effect when feasible. Otherwise monitor ECG and correct potassium and magnesium before and during therapy.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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