Drug interactions
Ofloxacin + Piroxicam
Severity: Moderate
Ofloxacin and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the seizure-provoking potential of fluoroquinolones such as ofloxacin. The risk is low but is greater in patients with epilepsy, CNS disease or renal impairment.
What this interaction means in plain words
Ofloxacin and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Piroxicam belongs to Musculoskeletal.
Why it happens
Fluoroquinolones antagonize GABA-A receptors and NSAIDs may enhance this effect, lowering seizure threshold.
What to do
Avoid the combination in patients with a seizure history or other predisposing factors. Otherwise use the lowest effective doses and counsel patients to report CNS symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Ofloxacin with Piroxicam?
MediHelp rates the interaction as moderate. Ofloxacin and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the seizure-provoking potential of fluoroquinolones such as ofloxacin. The risk is low but is greater in patients with epilepsy, CNS disease or renal impairment.
How serious is the interaction between Ofloxacin and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with a seizure history or other predisposing factors. Otherwise use the lowest effective doses and counsel patients to report CNS symptoms.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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