Drug interactions
Ofloxacin + Selinexor
Severity: Moderate
Ofloxacin and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological effects, and fluoroquinolones can also cause CNS adverse effects. Combined use may add to these effects, although a specific interaction is not well documented.
What this interaction means in plain words
Ofloxacin and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Selinexor belongs to Oncology.
Why it happens
Possible additive CNS toxicity; no specific pharmacokinetic mechanism is established.
What to do
Monitor for dizziness, confusion and falls, and counsel the patient about driving. Consider an alternative antibiotic if neurological symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Ofloxacin with Selinexor?
MediHelp rates the interaction as moderate. Ofloxacin and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological effects, and fluoroquinolones can also cause CNS adverse effects. Combined use may add to these effects, although a specific interaction is not well documented.
How serious is the interaction between Ofloxacin and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and falls, and counsel the patient about driving. Consider an alternative antibiotic if neurological symptoms develop.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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