Drug interactions
Ofloxacin + Solifenacin
Severity: Moderate
Ofloxacin and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin can prolong the QT interval, although less than some other fluoroquinolones, and solifenacin has a dose-related QT effect. Combined use may add to arrhythmia risk in predisposed patients.
What this interaction means in plain words
Ofloxacin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation.
What to do
Correct hypokalemia and hypomagnesemia and obtain an ECG in patients with cardiac risk factors. Choose a non-QT-prolonging antibiotic if the patient is at high risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Ofloxacin with Solifenacin?
MediHelp rates the interaction as moderate. Ofloxacin and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofloxacin can prolong the QT interval, although less than some other fluoroquinolones, and solifenacin has a dose-related QT effect. Combined use may add to arrhythmia risk in predisposed patients.
How serious is the interaction between Ofloxacin and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypokalemia and hypomagnesemia and obtain an ECG in patients with cardiac risk factors. Choose a non-QT-prolonging antibiotic if the patient is at high risk.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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