Drug interactions
Ofloxacin + Vemurafenib
Severity: Major
Ofloxacin and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval in an exposure-related way, and ofloxacin may contribute additional prolongation. This raises the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Ofloxacin and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ofloxacin belongs to Anti Bacterial; Vemurafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination and use a non-QT-prolonging antibiotic. If unavoidable, monitor ECG and electrolytes regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Ofloxacin with Vemurafenib?
MediHelp rates the interaction as major. Ofloxacin and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib can prolong the QT interval in an exposure-related way, and ofloxacin may contribute additional prolongation. This raises the risk of serious ventricular arrhythmias.
How serious is the interaction between Ofloxacin and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antibiotic. If unavoidable, monitor ECG and electrolytes regularly.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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