Drug interactions
Ofloxacin + Vorinostat
Severity: Moderate
Ofloxacin and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin and vorinostat each have the potential to lengthen the QTc interval. Combined use may raise the likelihood of ventricular arrhythmia, particularly in patients with electrolyte abnormalities.
What this interaction means in plain words
Ofloxacin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ofloxacin belongs to Anti Bacterial; Vorinostat belongs to Oncology.
Why it happens
Additive QT interval prolongation (pharmacodynamic).
What to do
Check ECG, potassium and magnesium at baseline and during treatment, and correct any deficits. Choose a non-QT-prolonging antibiotic if one is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Ofloxacin with Vorinostat?
MediHelp rates the interaction as moderate. Ofloxacin and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofloxacin and vorinostat each have the potential to lengthen the QTc interval. Combined use may raise the likelihood of ventricular arrhythmia, particularly in patients with electrolyte abnormalities.
How serious is the interaction between Ofloxacin and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG, potassium and magnesium at baseline and during treatment, and correct any deficits. Choose a non-QT-prolonging antibiotic if one is suitable.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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