Drug interactions
Olanzapine + Ondansetron
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Potential additive QTc prolongation; both agents can prolong QT (ondansetron > olanzapine).
Mechanism of action
Pharmacodynamic additive QT prolongation.
Clinical management
Use caution in patients with other QT risk factors; consider ECG monitoring; correct electrolytes; avoid high single IV doses of ondansetron.
Drug reference
References
- Zofran (ondansetron) Prescribing Information — FDA Label
- Zyprexa (olanzapine) Prescribing Information — FDA Label
- QT-Prolonging Agents (Drug Interactions) — Lexicomp
Frequently asked questions
Can I take Olanzapine with Ondansetron?
The interaction is rated: Moderate. Potential additive QTc prolongation; both agents can prolong QT (ondansetron > olanzapine).
How serious is the interaction between Olanzapine and Ondansetron?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between Olanzapine and Ondansetron managed?
Use caution in patients with other QT risk factors; consider ECG monitoring; correct electrolytes; avoid high single IV doses of ondansetron.
Why do Olanzapine and Ondansetron interact?
Pharmacodynamic additive QT prolongation.
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