Drug interactions
Olanzapine + Oxycodone
Severity: Moderate
Olanzapine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine and oxycodone both cause sedation, and together they can increase drowsiness, orthostatic hypotension and respiratory depression. Risk is greater with higher doses and in older adults.
What this interaction means in plain words
Olanzapine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Use the lowest effective doses and monitor for sedation, blood pressure drops and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Oxycodone?
MediHelp rates the interaction as moderate. Olanzapine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine and oxycodone both cause sedation, and together they can increase drowsiness, orthostatic hypotension and respiratory depression. Risk is greater with higher doses and in older adults.
How serious is the interaction between Olanzapine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, blood pressure drops and respiratory depression.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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