Drug interactions
Olanzapine + Ozanimod
Severity: Moderate
Olanzapine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and affect atrioventricular conduction, and olanzapine has modest QT effects. Combining them may increase the risk of bradycardia-related arrhythmia in susceptible patients.
What this interaction means in plain words
Olanzapine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive effects on cardiac conduction and repolarization, combining S1P receptor-mediated bradycardia with olanzapine's QT effect.
What to do
Obtain an ECG before starting ozanimod and consider cardiology advice for patients on QT-prolonging drugs. Monitor heart rate and rhythm after initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Olanzapine with Ozanimod?
MediHelp rates the interaction as moderate. Olanzapine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod can slow heart rate and affect atrioventricular conduction, and olanzapine has modest QT effects. Combining them may increase the risk of bradycardia-related arrhythmia in susceptible patients.
How serious is the interaction between Olanzapine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod and consider cardiology advice for patients on QT-prolonging drugs. Monitor heart rate and rhythm after initiation.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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