Drug interactions
Olanzapine + Panobinostat
Severity: Major
Olanzapine and Panobinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat can prolong the QT interval, and olanzapine may add a small effect. Panobinostat labeling advises against use with QT-prolonging drugs.
What this interaction means in plain words
Olanzapine and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Olanzapine belongs to Central Nervous System; Panobinostat belongs to Oncology.
Why it happens
Additive prolongation of the QT interval.
What to do
Avoid the combination if possible and use an antipsychotic with lower QT risk. If it cannot be avoided, check the ECG and electrolytes at baseline and regularly during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Olanzapine
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Olanzapine with Panobinostat?
MediHelp rates the interaction as major. Olanzapine and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat can prolong the QT interval, and olanzapine may add a small effect. Panobinostat labeling advises against use with QT-prolonging drugs.
How serious is the interaction between Olanzapine and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use an antipsychotic with lower QT risk. If it cannot be avoided, check the ECG and electrolytes at baseline and regularly during treatment.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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