Drug interactions
Olanzapine + Ranolazine
Severity: Moderate
Olanzapine and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, though olanzapine's effect is small. The combination adds modestly to arrhythmia risk.
What this interaction means in plain words
Olanzapine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain an ECG at baseline and after starting, and maintain normal potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Ranolazine?
MediHelp rates the interaction as moderate. Olanzapine and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, though olanzapine's effect is small. The combination adds modestly to arrhythmia risk.
How serious is the interaction between Olanzapine and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and after starting, and maintain normal potassium and magnesium.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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