Drug interactions
Olanzapine + Rucaparib
Severity: Moderate
Olanzapine and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a moderate CYP1A2 inhibitor and may raise exposure to CYP1A2 substrates. Olanzapine levels could increase, causing more sedation and other adverse effects.
What this interaction means in plain words
Olanzapine and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Inhibition of CYP1A2 by rucaparib reduces olanzapine clearance.
What to do
Monitor for olanzapine adverse effects such as sedation and orthostatic hypotension. Reduce the olanzapine dose if clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Olanzapine with Rucaparib?
MediHelp rates the interaction as moderate. Olanzapine and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib is a moderate CYP1A2 inhibitor and may raise exposure to CYP1A2 substrates. Olanzapine levels could increase, causing more sedation and other adverse effects.
How serious is the interaction between Olanzapine and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for olanzapine adverse effects such as sedation and orthostatic hypotension. Reduce the olanzapine dose if clinically indicated.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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