Drug interactions
Olanzapine + Sevoflurane
Severity: Moderate
Olanzapine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval and olanzapine has a small QT effect, so perioperative arrhythmia risk may rise slightly. Additive sedation and hypotension may also occur.
What this interaction means in plain words
Olanzapine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS depression.
What to do
Check baseline ECG and electrolytes before surgery and monitor ECG during anaesthesia. Avoid other QT-prolonging agents where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olanzapine and Sevoflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Olanzapine
Other interactions of Sevoflurane
Frequently asked questions
Can I take Olanzapine with Sevoflurane?
MediHelp rates the interaction as moderate. Olanzapine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval and olanzapine has a small QT effect, so perioperative arrhythmia risk may rise slightly. Additive sedation and hypotension may also occur.
How serious is the interaction between Olanzapine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes before surgery and monitor ECG during anaesthesia. Avoid other QT-prolonging agents where possible.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
