Drug interactions
Olanzapine + Stiripentol
Severity: Moderate
Olanzapine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol has mixed inhibitory and inducing effects on CYP1A2, so olanzapine exposure may change unpredictably. Both drugs also cause sedation, so somnolence may be additive.
What this interaction means in plain words
Olanzapine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol modulates CYP1A2 metabolism of olanzapine, and both agents add central nervous system depression.
What to do
Monitor sedation and clinical response to olanzapine when stiripentol is started or stopped, and adjust the olanzapine dose according to effect and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Stiripentol
Frequently asked questions
Can I take Olanzapine with Stiripentol?
MediHelp rates the interaction as moderate. Olanzapine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol has mixed inhibitory and inducing effects on CYP1A2, so olanzapine exposure may change unpredictably. Both drugs also cause sedation, so somnolence may be additive.
How serious is the interaction between Olanzapine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and clinical response to olanzapine when stiripentol is started or stopped, and adjust the olanzapine dose according to effect and tolerability.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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