Drug interactions
Olanzapine + Tramadol
Severity: Moderate
Olanzapine and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause CNS depression, so combined use can increase drowsiness, dizziness and impaired psychomotor function. Both can also lower the seizure threshold, and tramadol is an opioid with respiratory depressant effects.
What this interaction means in plain words
Olanzapine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Tramadol belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects and additive lowering of the seizure threshold.
What to do
Start with low tramadol doses and monitor sedation and respiratory status. Advise the patient to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Tramadol?
MediHelp rates the interaction as moderate. Olanzapine and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause CNS depression, so combined use can increase drowsiness, dizziness and impaired psychomotor function. Both can also lower the seizure threshold, and tramadol is an opioid with respiratory depressant effects.
How serious is the interaction between Olanzapine and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low tramadol doses and monitor sedation and respiratory status. Advise the patient to avoid driving and alcohol.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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