Drug interactions
Olanzapine + Trimipramine
Severity: Moderate
Olanzapine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and anticholinergic, and each has some capacity to prolong the QT interval. Combined use can increase drowsiness, confusion, constipation and urinary retention, with a small added arrhythmia risk.
What this interaction means in plain words
Olanzapine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression, anticholinergic effects and QT prolongation.
What to do
Monitor sedation and anticholinergic effects, and obtain an ECG in patients with cardiac risk factors or electrolyte disturbance. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Olanzapine
Frequently asked questions
Can I take Olanzapine with Trimipramine?
MediHelp rates the interaction as moderate. Olanzapine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and anticholinergic, and each has some capacity to prolong the QT interval. Combined use can increase drowsiness, confusion, constipation and urinary retention, with a small added arrhythmia risk.
How serious is the interaction between Olanzapine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and anticholinergic effects, and obtain an ECG in patients with cardiac risk factors or electrolyte disturbance. Use the lowest effective doses.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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