Drug interactions
Olanzapine + Valbenazine
Severity: Moderate
Olanzapine and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine can prolong the QT interval at higher exposures, and olanzapine has a small QT effect. Combined use may add to arrhythmia risk, and both drugs may cause somnolence.
What this interaction means in plain words
Olanzapine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olanzapine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS depressant effects.
What to do
Consider an ECG in patients with cardiac risk factors or other QT-prolonging drugs, and monitor for sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Olanzapine with Valbenazine?
MediHelp rates the interaction as moderate. Olanzapine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine can prolong the QT interval at higher exposures, and olanzapine has a small QT effect. Combined use may add to arrhythmia risk, and both drugs may cause somnolence.
How serious is the interaction between Olanzapine and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG in patients with cardiac risk factors or other QT-prolonging drugs, and monitor for sedation.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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