Drug interactions
Olanzapine / samidorphan + Tiotropium-olodaterol
Severity: Moderate
Olanzapine / samidorphan and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has anticholinergic activity and tiotropium is an antimuscarinic. The combination increases anticholinergic burden, with constipation, urinary retention, dry mouth and in severe cases reduced gastrointestinal motility.
What this interaction means in plain words
Olanzapine / samidorphan and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor bowel function, urinary symptoms and intraocular pressure complaints. Counsel patients to report severe constipation or abdominal pain promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Olanzapine / samidorphan with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has anticholinergic activity and tiotropium is an antimuscarinic. The combination increases anticholinergic burden, with constipation, urinary retention, dry mouth and in severe cases reduced gastrointestinal motility.
How serious is the interaction between Olanzapine / samidorphan and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function, urinary symptoms and intraocular pressure complaints. Counsel patients to report severe constipation or abdominal pain promptly.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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