Drug interactions
Olanzapine / samidorphan + Trazodone
Severity: Moderate
Olanzapine / samidorphan and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both trazodone and olanzapine cause sedation and orthostatic hypotension, so combined use can increase dizziness, falls and drowsiness. Both can also prolong the QT interval to a small extent.
What this interaction means in plain words
Olanzapine / samidorphan and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and alpha-1 adrenergic blockade from olanzapine and trazodone.
What to do
Monitor sedation and orthostatic blood pressure, particularly when starting or raising doses. Counsel patients to rise slowly, and consider an ECG if other QT-prolonging drugs are taken.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Olanzapine / samidorphan and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Trazodone?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both trazodone and olanzapine cause sedation and orthostatic hypotension, so combined use can increase dizziness, falls and drowsiness. Both can also prolong the QT interval to a small extent.
How serious is the interaction between Olanzapine / samidorphan and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, particularly when starting or raising doses. Counsel patients to rise slowly, and consider an ECG if other QT-prolonging drugs are taken.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
