Drug interactions
Olanzapine / samidorphan + Trimipramine
Severity: Moderate
Olanzapine / samidorphan and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both olanzapine and trimipramine cause sedation, orthostatic hypotension and anticholinergic effects, so these are additive when combined. Falls, syncope and cognitive impairment are the main concerns, particularly in older patients.
What this interaction means in plain words
Olanzapine / samidorphan and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant, alpha-adrenergic blocking and antimuscarinic effects.
What to do
Monitor sitting and standing blood pressure, sedation and anticholinergic symptoms, and titrate doses slowly. Counsel patients on rising slowly and avoiding alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Trimipramine?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both olanzapine and trimipramine cause sedation, orthostatic hypotension and anticholinergic effects, so these are additive when combined. Falls, syncope and cognitive impairment are the main concerns, particularly in older patients.
How serious is the interaction between Olanzapine / samidorphan and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sitting and standing blood pressure, sedation and anticholinergic symptoms, and titrate doses slowly. Counsel patients on rising slowly and avoiding alcohol.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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