Drug interactions
Olanzapine / samidorphan + Vortioxetine
Severity: Moderate
Olanzapine / samidorphan and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine causes sedation and orthostatic hypotension, which may be additive with other CNS-active drugs. Vortioxetine adds modest CNS effects, and both drugs can carry a small serotonergic or dizziness burden.
What this interaction means in plain words
Olanzapine / samidorphan and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and orthostatic effects through pharmacodynamic overlap.
What to do
Monitor for sedation, dizziness and orthostatic hypotension, particularly at initiation and dose increases. Advise patients to rise slowly and to avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Olanzapine / samidorphan with Vortioxetine?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine causes sedation and orthostatic hypotension, which may be additive with other CNS-active drugs. Vortioxetine adds modest CNS effects, and both drugs can carry a small serotonergic or dizziness burden.
How serious is the interaction between Olanzapine / samidorphan and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and orthostatic hypotension, particularly at initiation and dose increases. Advise patients to rise slowly and to avoid alcohol.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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