Drug interactions
Olanzapine / samidorphan + Zileuton
Severity: Moderate
Olanzapine / samidorphan and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton inhibits CYP1A2 and may increase olanzapine concentrations. This can heighten sedation, orthostatic hypotension and other olanzapine adverse effects.
What this interaction means in plain words
Olanzapine / samidorphan and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP1A2 by zileuton decreases olanzapine metabolism.
What to do
Monitor for sedation, hypotension and anticholinergic effects, and consider lowering the olanzapine dose if adverse effects appear. Reassess if zileuton is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Frequently asked questions
Can I take Olanzapine / samidorphan with Zileuton?
MediHelp rates the interaction as moderate. Olanzapine / samidorphan and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zileuton inhibits CYP1A2 and may increase olanzapine concentrations. This can heighten sedation, orthostatic hypotension and other olanzapine adverse effects.
How serious is the interaction between Olanzapine / samidorphan and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension and anticholinergic effects, and consider lowering the olanzapine dose if adverse effects appear. Reassess if zileuton is stopped.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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