Drug interactions
Olaparib + Zileuton
Severity: Moderate
Olaparib and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olaparib is cleared by CYP3A4 and zileuton is a weak inhibitor, so olaparib exposure may increase slightly. This could worsen anemia, nausea, fatigue and other olaparib toxicities.
What this interaction means in plain words
Olaparib and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Olaparib belongs to Oncology; Zileuton belongs to Respiratory.
Why it happens
Zileuton inhibition of CYP3A4 metabolism of olaparib.
What to do
No routine dose reduction is needed for weak inhibitors; monitor blood counts and tolerability. Reduce the olaparib dose if hematologic or other toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Olaparib with Zileuton?
MediHelp rates the interaction as moderate. Olaparib and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olaparib is cleared by CYP3A4 and zileuton is a weak inhibitor, so olaparib exposure may increase slightly. This could worsen anemia, nausea, fatigue and other olaparib toxicities.
How serious is the interaction between Olaparib and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose reduction is needed for weak inhibitors; monitor blood counts and tolerability. Reduce the olaparib dose if hematologic or other toxicity develops.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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