Drug interactions
Oliceridine + Orphenadrin
Severity: Major
Oliceridine and Orphenadrin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining oliceridine, an opioid, with orphenadrine, a sedating anticholinergic, may cause profound sedation, respiratory depression, coma and death. Anticholinergic effects may also add to opioid-related constipation and urinary retention.
What this interaction means in plain words
Oliceridine and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression, with additive anticholinergic effects.
What to do
Avoid the combination where possible; if needed, use the lowest doses for the shortest time. Monitor for sedation and respiratory depression and for constipation or urinary retention.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Orphenadrin
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Orphenadrin?
MediHelp rates the interaction as major. Oliceridine and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining oliceridine, an opioid, with orphenadrine, a sedating anticholinergic, may cause profound sedation, respiratory depression, coma and death. Anticholinergic effects may also add to opioid-related constipation and urinary retention.
How serious is the interaction between Oliceridine and Orphenadrin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, use the lowest doses for the shortest time. Monitor for sedation and respiratory depression and for constipation or urinary retention.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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