Drug interactions
Oliceridine + Oxymorphone
Severity: Major
Oliceridine and Oxymorphone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two opioid agonists given together add to sedation, respiratory depression and overdose risk. Duplicate opioid therapy can cause profound sedation and death.
What this interaction means in plain words
Oliceridine and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive mu-opioid receptor agonism producing CNS and respiratory depression.
What to do
Avoid overlapping use unless necessary, limit dose and duration, and titrate oliceridine to effect with oxymorphone exposure taken into account. Monitor respiratory rate and sedation closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Oxymorphone?
MediHelp rates the interaction as major. Oliceridine and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two opioid agonists given together add to sedation, respiratory depression and overdose risk. Duplicate opioid therapy can cause profound sedation and death.
How serious is the interaction between Oliceridine and Oxymorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid overlapping use unless necessary, limit dose and duration, and titrate oliceridine to effect with oxymorphone exposure taken into account. Monitor respiratory rate and sedation closely.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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