Drug interactions
Oliceridine + Quetiapine
Severity: Major
Oliceridine and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with sedating antipsychotics can cause profound sedation, respiratory depression, coma and death. Oliceridine is a potent intravenous opioid, so additive depression of consciousness and breathing is a real concern.
What this interaction means in plain words
Oliceridine and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression from mu-opioid agonism and quetiapine sedation.
What to do
Use the lowest effective oliceridine dose for the shortest time and monitor sedation and respiratory status continuously. Reserve the combination for patients with no adequate alternative.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Quetiapine?
MediHelp rates the interaction as major. Oliceridine and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with sedating antipsychotics can cause profound sedation, respiratory depression, coma and death. Oliceridine is a potent intravenous opioid, so additive depression of consciousness and breathing is a real concern.
How serious is the interaction between Oliceridine and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oliceridine dose for the shortest time and monitor sedation and respiratory status continuously. Reserve the combination for patients with no adequate alternative.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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