Drug interactions
Oliceridine + Quinidine
Severity: Moderate
Oliceridine and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits CYP2D6, a major oliceridine pathway, and may raise its exposure. This increases the risk of respiratory depression and sedation.
What this interaction means in plain words
Oliceridine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Quinidine belongs to Anti Parasitic.
Why it happens
CYP2D6 inhibition reduces oliceridine metabolism.
What to do
Use less frequent oliceridine dosing and monitor for sedation and respiratory depression. If quinidine is stopped, reassess dose and watch for withdrawal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Quinidine?
MediHelp rates the interaction as moderate. Oliceridine and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits CYP2D6, a major oliceridine pathway, and may raise its exposure. This increases the risk of respiratory depression and sedation.
How serious is the interaction between Oliceridine and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use less frequent oliceridine dosing and monitor for sedation and respiratory depression. If quinidine is stopped, reassess dose and watch for withdrawal.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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