Drug interactions
Oliceridine + Secobarbital
Severity: Major
Oliceridine and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a barbiturate with an opioid causes additive sedation and respiratory depression that can be profound. Secobarbital also induces CYP3A4, which may lower oliceridine levels and reduce analgesia, with a rebound in opioid effect when the inducer is stopped.
What this interaction means in plain words
Oliceridine and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Secobarbital belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression, plus CYP3A4 induction that increases oliceridine clearance.
What to do
Reserve for patients without alternatives and use the lowest effective doses while monitoring sedation and respiration. Adjust oliceridine dose if the inducer is started or stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Secobarbital?
MediHelp rates the interaction as major. Oliceridine and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a barbiturate with an opioid causes additive sedation and respiratory depression that can be profound. Secobarbital also induces CYP3A4, which may lower oliceridine levels and reduce analgesia, with a rebound in opioid effect when the inducer is stopped.
How serious is the interaction between Oliceridine and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve for patients without alternatives and use the lowest effective doses while monitoring sedation and respiration. Adjust oliceridine dose if the inducer is started or stopped.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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