Drug interactions
Oliceridine + Sertraline
Severity: Moderate
Oliceridine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is metabolized by CYP2D6 and CYP3A4, and sertraline inhibits both weakly to moderately, which may raise oliceridine levels. This increases the risk of sedation and respiratory depression, and combined serotonergic effects are also possible.
What this interaction means in plain words
Oliceridine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6 and CYP3A4 by sertraline reduces oliceridine clearance, with some additive serotonergic effects.
What to do
Titrate oliceridine carefully and monitor for respiratory depression and sedation. Consider longer dosing intervals, and watch for serotonin syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Sertraline?
MediHelp rates the interaction as moderate. Oliceridine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is metabolized by CYP2D6 and CYP3A4, and sertraline inhibits both weakly to moderately, which may raise oliceridine levels. This increases the risk of sedation and respiratory depression, and combined serotonergic effects are also possible.
How serious is the interaction between Oliceridine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate oliceridine carefully and monitor for respiratory depression and sedation. Consider longer dosing intervals, and watch for serotonin syndrome.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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