Drug interactions
Oliceridine + Sumatriptan
Severity: Moderate
Oliceridine and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with serotonergic activity are linked to serotonin syndrome when given with triptans. Oliceridine is a mu-opioid agonist with limited direct serotonergic action, so the risk is probably low but the labeling cautions about it.
What this interaction means in plain words
Oliceridine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Sumatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effect; oliceridine's contribution is not well established.
What to do
Monitor for serotonin syndrome when the two are used together, especially after dose changes. Stop the serotonergic agents if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Sumatriptan?
MediHelp rates the interaction as moderate. Oliceridine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids with serotonergic activity are linked to serotonin syndrome when given with triptans. Oliceridine is a mu-opioid agonist with limited direct serotonergic action, so the risk is probably low but the labeling cautions about it.
How serious is the interaction between Oliceridine and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome when the two are used together, especially after dose changes. Stop the serotonergic agents if symptoms occur.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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