Drug interactions
Oliceridine + Terbinafine
Severity: Moderate
Oliceridine and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is partly cleared by CYP2D6, so terbinafine may increase its exposure. This could enhance sedation and respiratory depression.
What this interaction means in plain words
Oliceridine and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Terbinafine belongs to Anti Fungals.
Why it happens
Terbinafine inhibits CYP2D6, reducing oliceridine clearance.
What to do
Monitor for sedation and respiratory depression and use less frequent or lower doses; reassess dosing if terbinafine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Terbinafine?
MediHelp rates the interaction as moderate. Oliceridine and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oliceridine is partly cleared by CYP2D6, so terbinafine may increase its exposure. This could enhance sedation and respiratory depression.
How serious is the interaction between Oliceridine and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and use less frequent or lower doses; reassess dosing if terbinafine is stopped.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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