Drug interactions
Oliceridine + Tranylcypromine
Severity: Major
Oliceridine and Tranylcypromine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can precipitate serotonin syndrome or, with some opioids, severe reactions when combined with MAOIs. Tranylcypromine may also raise oliceridine exposure through CYP2D6 inhibition, increasing the risk of respiratory depression.
What this interaction means in plain words
Oliceridine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oliceridine belongs to Musculoskeletal; Tranylcypromine belongs to Central Nervous System.
Why it happens
Serotonergic excess plus CYP2D6 inhibition, and additive opioid CNS depression.
What to do
Avoid concurrent use where possible, including within 14 days of stopping an MAOI. If it is unavoidable, use reduced doses and monitor for respiratory depression, sedation and serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Tranylcypromine?
MediHelp rates the interaction as major. Oliceridine and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids can precipitate serotonin syndrome or, with some opioids, severe reactions when combined with MAOIs. Tranylcypromine may also raise oliceridine exposure through CYP2D6 inhibition, increasing the risk of respiratory depression.
How serious is the interaction between Oliceridine and Tranylcypromine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, including within 14 days of stopping an MAOI. If it is unavoidable, use reduced doses and monitor for respiratory depression, sedation and serotonin toxicity.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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