Drug interactions
Oliceridine + Verapamil
Severity: Moderate
Oliceridine and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and may raise oliceridine exposure, increasing the risk of respiratory depression and sedation. Stopping verapamil later could lower oliceridine levels and reduce analgesia.
What this interaction means in plain words
Oliceridine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oliceridine belongs to Musculoskeletal; Verapamil belongs to Cardiovascular.
Why it happens
Moderate CYP3A4 inhibition by verapamil reduces the metabolic clearance of oliceridine, a CYP3A4 substrate.
What to do
Monitor for sedation and respiratory depression and titrate oliceridine to effect, using less frequent dosing if needed. If verapamil is withdrawn, reassess analgesia and adjust the oliceridine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Oliceridine with Verapamil?
MediHelp rates the interaction as moderate. Oliceridine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits CYP3A4 and may raise oliceridine exposure, increasing the risk of respiratory depression and sedation. Stopping verapamil later could lower oliceridine levels and reduce analgesia.
How serious is the interaction between Oliceridine and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and titrate oliceridine to effect, using less frequent dosing if needed. If verapamil is withdrawn, reassess analgesia and adjust the oliceridine dose.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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