Drug interactions
Olmesartan + Pretomanid
Severity: Minor
Olmesartan and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid may inhibit OATP1B3, a transporter involved in hepatic uptake of olmesartan, potentially raising olmesartan exposure. The clinical effect is expected to be modest, mainly increased hypotension or renal effects.
What this interaction means in plain words
Olmesartan and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Olmesartan belongs to Cardiovascular; Pretomanid belongs to Anti Bacterial.
Why it happens
Inhibition of OATP1B3-mediated hepatic uptake of olmesartan by pretomanid.
What to do
Monitor blood pressure and renal function while both are given, and reduce the olmesartan dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Other interactions of Pretomanid
Frequently asked questions
Can I take Olmesartan with Pretomanid?
MediHelp rates the interaction as minor. Olmesartan and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid may inhibit OATP1B3, a transporter involved in hepatic uptake of olmesartan, potentially raising olmesartan exposure. The clinical effect is expected to be modest, mainly increased hypotension or renal effects.
How serious is the interaction between Olmesartan and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function while both are given, and reduce the olmesartan dose if hypotension occurs.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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