Drug interactions
Olodaterol inhaled + Sotalol
Severity: Major
Olodaterol inhaled and Sotalol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a non-selective beta-blocker that can oppose the bronchodilation of olodaterol and may precipitate bronchospasm in patients with COPD or asthma. Both bronchodilator efficacy and respiratory safety are affected.
What this interaction means in plain words
Olodaterol inhaled and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors.
What to do
Avoid sotalol in patients using olodaterol where possible and select an alternative antiarrhythmic. If a beta-blocker is essential, use a cardioselective agent and monitor respiratory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Olodaterol inhaled with Sotalol?
MediHelp rates the interaction as major. Olodaterol inhaled and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is a non-selective beta-blocker that can oppose the bronchodilation of olodaterol and may precipitate bronchospasm in patients with COPD or asthma. Both bronchodilator efficacy and respiratory safety are affected.
How serious is the interaction between Olodaterol inhaled and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sotalol in patients using olodaterol where possible and select an alternative antiarrhythmic. If a beta-blocker is essential, use a cardioselective agent and monitor respiratory function.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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